Publications at HKU
2024
Cobalt-Catalyzed Desymmetrization of Malononitriles via Enantioselective Borohydride Reduction
Zheng, Yin;^ Yang, T.;^ Chan, K. F.; Lin, Z.*; Huang, Z.*, Nat. Chem. 2024, 16, 1845. [link]
(^ equal contribution)
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Highlighted by C. Philipson, R. H. Hoogestger and C. P. Johnston in Trends in Chemistry, 'Mind the gap! Steric-driven reductive desymmetrisation of malononitriles'
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Highlighted by C. E. Johnson and M. Lautens in Synfacts.
2023
Modular and Diverse Synthesis of Amino Acids via Asymmetric Decarboxylative Protonation of Aminomalonic Acids
Zheng, Wei-Feng; Chen, J. (UG); Qi, X.*; Huang, Z.*, Nat. Chem. 2023, 15, 1672. [link]
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Highlighted by X. Lin and A. G. Woldegiorgis in Nature Chemistry, 'An acid for an acid'
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Highlighted by R. Xu and B. List in Synfacts.
Zinc-Catalyzed Desymmetric Hydrosilylation of Monosubstituted Malonic Esters
Zhang, Yixiao; Xu, P.; Zhao, Q.; Wang, J. ; Huang, Z.*, Org. Chem. Front. 2023, 10, 1675. [Link]
(invited article for emerging investigator series)
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Featured in Organic Chemistry Portal.
2022
Diverse Synthesis of α-Tertiary Amines and Tertiary Alcohols via Desymmetric Reduction of Malonic Esters
Liu, Haichao; Lau, H. M.; Xu, P.; Chan, T. H. (UG); Huang, Z.*, Nat. Commun. 2022, 13, 4759. [Link]
Desymmetric Cyanosilylation of Acyclic 1,3-Diketones
Xu, Pan; Shen, C.; Xu, A.; Low, K.-H.; Huang, Z.*, Angew. Chem. Int. Ed. 2022, 61. e202208443. [Link]
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Featured in Angewandte Chemie Author Profile.
Desymmetric Partial Reduction of Malonic Esters
Xu, Pengwei; Liu, S.; Huang, Z.*, J. Am. Chem. Soc. 2022, 144, 6918-6927. [Link]
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Selected by ACS Editors' Choice.
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Highlighted by S. Chakrabarty in JACS Spotlights, 2022, 144, 6623-6624.
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Featured in Organic Chemistry Portal.
A Unified and Desymmetric Approach to Chiral Tertiary Alkyl Halides
Zheng, Yin; Zhang, S. (UG); Low, K.-H.; Zi, W.; Huang, Z.*, J. Am. Chem. Soc. 2022, 144, 1951-1961. [Link]
Sewing Molecules Together with Light
Xu, Pan; Huang, Z.*, Trends Chem. 2022, 4, 169-171 (invited Spotlight). [Link]
2021
Catalytic Reductive Desymmetrization of Malonic Esters
Xu, Pengwei; Huang, Z.*, Nat. Chem. 2021, 13, 634-642. [Link]
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Highlighted by J. Gajewy and M. Kwit in Nature Chemistry, 'The gains from breaking symmetry'
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Highlighted by L. Boerner in C&EN News, 'Reduction carves path to chiral compounds'
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Highlighted by G. R. Stephenson in Chemistry&Industry.
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Featured in Organic Chemistry Portal.
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Featured in X-mol.