Publications at HKU
2023
Modular and Diverse Synthesis of Amino Acids via Asymmetric Decarboxylative Protonation of Aminomalonic Acids
Zheng, Wei-Feng; Chen, J. (UG); Qi, X.*; Huang, Z.*, Nat. Chem. 2023, accepted. [link]
Zinc-Catalyzed Desymmetric Hydrosilylation of Monosubstituted Malonic Esters
Zhang, Yixiao; Xu, P.; Zhao, Q.; Wang, J. ; Huang, Z.*, Org. Chem. Front. 2023, 10, 1675. [Link]
(invited article for emerging investigator series)
2022
Diverse Synthesis of α-Tertiary Amines and Tertiary Alcohols via Desymmetric Reduction of Malonic Esters
Liu, Haichao; Lau, H. M.; Xu, P.; Chan, T. H. (UG); Huang, Z.*, Nat. Commun. 2022, 13, 4759. [Link]
Desymmetric Cyanosilylation of Acyclic 1,3-Diketones
Xu, Pan; Shen, C.; Xu, A.; Low, K.-H.; Huang, Z.*, Angew. Chem. Int. Ed. 2022, 61. e202208443. [Link]
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Featured in Angewandte Chemie Author Profile.
Desymmetric Partial Reduction of Malonic Esters
Xu, Pengwei; Liu, S.; Huang, Z.*, J. Am. Chem. Soc. 2022, 144, 6918-6927. [Link]
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Selected by ACS Editors' Choice.
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Highlighted by S. Chakrabarty in JACS Spotlights, 2022, 144, 6623-6624.
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Featured in Organic Chemistry Portal.
A Unified and Desymmetric Approach to Chiral Tertiary Alkyl Halides
Zheng, Yin; Zhang, S. (UG); Low, K.-H.; Zi, W.; Huang, Z.*, J. Am. Chem. Soc. 2022, 144, 1951-1961. [Link]
Sewing Molecules Together with Light
Xu, Pan; Huang, Z.*, Trends Chem. 2022, 4, 169-171 (invited Spotlight). [Link]
2021
Catalytic Reductive Desymmetrization of Malonic Esters
Xu, Pengwei; Huang, Z.*, Nat. Chem. 2021, 13, 634-642. [Link]
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Highlighted by J. Gajewy and M. Kwit in Nature Chemistry, 'The gains from breaking symmetry'
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Highlighted by L. Boerner in C&EN News, 'Reduction carves path to chiral compounds'
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Highlighted by G. R. Stephenson in Chemistry&Industry.
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Featured in Organic Chemistry Portal.
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Featured in X-mol.
Selected Publications before HKU
Total Synthesis of Bryostatin 3
Trost, B. M.*; Wang, Y.; Buckl, A. K.; Huang, Z.; Nguyen, M. H.; Kuzmina, O., Science 2020, 368, 1007. [Link]
Catalytic (3+2) Palladium‐Aminoallyl Cycloaddition with Conjugated Dienes
Trost, B. M.*; Huang, Z., Angew. Chem. Int. Ed. 2019, 58, 6396. [Link]
Catalytic Palladium-Oxyallyl Cycloaddition
Trost, B. M.*; Huang, Z.; Murhade, G. M., Science 2018, 362, 564. [Link]
Palladium-Catalyzed Redox Cascade for Direct β-Arylation of Ketones
Huang, Z.; Dong, G.*, Tetrahedron 2018, 74, 3253. [Link]
Site-Selectivity Control in Organic Reactions: A Quest to Differentiate Reactivity among the Same Kind of Functional Groups
Huang, Z.; Dong, G.*, Acc. Chem. Res. 2017, 50, 465. [Link]
A Hydrazone-Based Directing Group Strategy for β-C−H Oxidation of Aliphatic Amines
Huang, Z.; Wang, C.; Dong, G.*, Angew. Chem. Int. Ed. 2016, 55, 5209. [Link]
Transition Metal-Catalyzed Ketone-Directed or Mediated C−H Functionalization
Huang, Z.; Lim, H. N.; Mo, F.; Young, M.; Dong, G.*, Chem. Soc. Rev. 2015, 44, 7764. [Link]
Palladium-Catalyzed Direct β-Arylation of Ketones with Diaryliodonium Salts: a Stoichiometric Heavy Metal-Free and User-Friendly Approach
Huang, Z.; Sam, Q. P.; Dong, G.*, Chem. Sci. 2015, 6, 5491. [Link]
Catalytic C−C Bond Forming Transformations via Direct β-C−H Functionalization of Carbonyl Compounds
Huang, Z.; Dong, G.*, Tetrahedron Lett. 2014, 55, 5869. [Link]
Catalytic Direct β-Arylation of Simple Ketones with Aryl Iodides
Huang, Z.; Dong, G.*, J. Am. Chem. Soc. 2013, 135, 17747. [Link]
Auto-Tandem Catalysis: Synthesis of Acridines by Pd-Catalyzed C=C Bond Formation and C(sp2)−N Cross-Coupling
Huang, Z.; Yang, Y.; Xiao, Q.; Zhang, Y.*; Wang, J.*, Eur. J. Org. Chem. 2012, 6586. [Link]