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Publications at HKU


Modular and Diverse Synthesis of Amino Acids via Asymmetric Decarboxylative Protonation of Aminomalonic Acids

Zheng, Wei-Feng; Chen, J. (UG); Qi, X.*; Huang, Z.*, Nat. Chem. 2023, accepted. [link]

Zinc-Catalyzed Desymmetric Hydrosilylation of Monosubstituted Malonic Esters

Zhang, Yixiao; Xu, P.; Zhao, Q.; Wang, J. ; Huang, Z.*, Org. Chem. Front. 2023, 10, 1675. [Link]

(invited article for emerging investigator series)

2023 OCF Zhang Yixiao


Diverse Synthesis of α-Tertiary Amines and Tertiary Alcohols via Desymmetric Reduction of Malonic Esters

Liu, Haichao; Lau, H. M.; Xu, P.; Chan, T. H. (UG); Huang, Z.*, Nat. Commun. 2022, 13, 4759. [Link]

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  • Highlighted by H. Yamamoto, and T. Hattori in Synfacts.

Desymmetric Cyanosilylation of Acyclic 1,3-Diketones

Xu, Pan; Shen, C.; Xu, A.; Low, K.-H.; Huang, Z.*, Angew. Chem. Int. Ed. 2022, 61. e202208443. [Link]

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Desymmetric Partial Reduction of Malonic Esters

Xu, Pengwei; Liu, S.; Huang, Z.*, J. Am. Chem. Soc. 2022, 144​, 6918-6927. [Link]

2022 JACS Xu Pengwei


A Unified and Desymmetric Approach to Chiral Tertiary Alkyl Halides

Zheng, Yin; Zhang, S. (UG); Low, K.-H.; Zi, W.; Huang, Z.*, J. Am. Chem. Soc. 2022, 144, 1951-1961. [Link]

2022 JACS Zheng Yin
  • Highlighted by M. Oestreich, H. F. T. Klare, and N. Kranidiotis-Hisatomi in Synfacts.

Sewing Molecules Together with Light

Xu, Pan; Huang, Z.*, Trends Chem. 2022, 4, 169-171 (invited Spotlight). [Link]


Catalytic Reductive Desymmetrization of Malonic Esters

Xu, Pengwei; Huang, Z.*, Nat. Chem. 2021, 13, 634-642. [Link]

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Selected Publications before HKU

Total Synthesis of Bryostatin 3

Trost, B. M.*; Wang, Y.; Buckl, A. K.; Huang, Z.; Nguyen, M. H.; Kuzmina, O., Science 2020, 368, 1007. [Link]

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Catalytic (3+2) Palladium‐Aminoallyl Cycloaddition with Conjugated Dienes

Trost, B. M.*; Huang, Z., Angew. Chem. Int. Ed. 2019, 58, 6396. [Link]

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Catalytic Palladium-Oxyallyl Cycloaddition

Trost, B. M.*; Huang, Z.; Murhade, G. M., Science 2018, 362, 564. [Link]

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Palladium-Catalyzed Redox Cascade for Direct β-Arylation of Ketones

Huang, Z.; Dong, G.*, Tetrahedron 2018, 74, 3253. [Link]

Site-Selectivity Control in Organic Reactions: A Quest to Differentiate Reactivity among the Same Kind of Functional Groups

Huang, Z.; Dong, G.*, Acc. Chem. Res. 2017, 50, 465. [Link]

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A Hydrazone-Based Directing Group Strategy for β-C−H Oxidation of Aliphatic Amines

Huang, Z.; Wang, C.; Dong, G.*, Angew. Chem. Int. Ed. 2016, 55, 5209. [Link]

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Transition Metal-Catalyzed Ketone-Directed or Mediated C−H Functionalization

Huang, Z.; Lim, H. N.; Mo, F.; Young, M.; Dong, G.*, Chem. Soc. Rev. 2015, 44, 7764. [Link]


Palladium-Catalyzed Direct β-Arylation of Ketones with Diaryliodonium Salts: a Stoichiometric Heavy Metal-Free and User-Friendly Approach

Huang, Z.; Sam, Q. P.; Dong, G.*, Chem. Sci. 2015, 6, 5491. [Link]

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Catalytic C−C Bond Forming Transformations via Direct β-C−H Functionalization of Carbonyl Compounds

Huang, Z.; Dong, G.*, Tetrahedron Lett. 2014, 55, 5869. [Link]

Catalytic Direct β-Arylation of Simple Ketones with Aryl Iodides

Huang, Z.; Dong, G.*, J. Am. Chem. Soc. 2013, 135, 17747. [Link]

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Auto-Tandem Catalysis: Synthesis of Acridines by Pd-Catalyzed C=C Bond Formation and C(sp2)−N Cross-Coupling

Huang, Z.; Yang, Y.; Xiao, Q.; Zhang, Y.*; Wang, J.*, Eur. J. Org. Chem. 2012, 6586. [Link]

The Huang Group at HKU


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